Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | KDM1A | O60341 | 8/20 | 0.53 |
| ▸ | EHMT2 | Q96KQ7 | 6/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | RCOR1 | Q9UKL0 | 7/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TERT | O14746 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14585340 | 0.94 | KDM1A (0.52) | RAD52POLBRXFP1KDM1AEHMT2 | |
| SCHEMBL14585305 | 0.91 | POLB (0.61) | RAD52POLBRXFP1KDM1AEHMT2 | |
| SCHEMBL4631081 | 0.90 | KDM1A (0.63) | RAD52POLBRXFP1KDM1AEHMT2 | |
| SCHEMBL14585335 | 0.89 | KDM1A (0.54) | RAD52POLBRXFP1KDM1AEHMT2 | |
| SCHEMBL14628154 | 0.88 | KDM1A (0.54) | RAD52POLBRXFP1KDM1AEHMT2 | |
| SCHEMBL14585299 | 0.88 | KDM1A (0.54) | RAD52POLBRXFP1KDM1AEHMT2 | |
| SCHEMBL14585342 | 0.88 | KDM1A (0.54) | RAD52POLBRXFP1KDM1AEHMT2 | |
| SCHEMBL14628243 | 0.88 | KDM1A (0.54) | RAD52POLBRXFP1KDM1AEHMT2 | |
| SCHEMBL14585311 | 0.88 | KDM1A (0.56) | RAD52POLBKDM1AEHMT2FLT3 | |
| SCHEMBL14585316 | 0.88 | KDM1A (0.53) | RAD52POLBRXFP1KDM1AEHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070032502-A1 | Quinazoline derivatives useful in cancer treatment | SCHERING CORPORATION | 2007-02-08 | — | — | US | disclosed |
| US-20070032502-A1 | Quinazoline derivatives useful in cancer treatment | SCHERING CORPORATION | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032502-A1 | Quinazoline derivatives useful in cancer treatment | TP53, ACIN1, TP53BP1 | RAD52 920/4885POLB 1010/4885RXFP1 1164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.