Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.50 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.50 |
| ▸ | ACP1 | P24666 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | RAD52 | P43351 | 5/20 | 0.45 |
| ▸ | TERT | O14746 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14585358 | 0.85 | KDM1A (0.53) | KDM1AEHMT2ALDH1A1MAPK1RAD52 | |
| SCHEMBL14585779 | 0.85 | ALDH1A1 (0.56) | KDM1AEHMT2ALDH1A1MAPK1RAD52 | |
| SCHEMBL14585400 | 0.84 | KDM1A (0.49) | KDM1AEHMT2ACP1ALDH1A1MAPK1 | |
| SCHEMBL14585310 | 0.84 | KDM1A (0.54) | KDM1AEHMT2ACP1ALDH1A1MAPK1 | |
| SCHEMBL14585296 | 0.84 | ALDH1A1 (0.51) | KDM1AEHMT2ACP1ALDH1A1MAPK1 | |
| SCHEMBL14585297 | 0.83 | MAPK1 (0.50) | KDM1AEHMT2ACP1ALDH1A1MAPK1 | |
| SCHEMBL14585356 | 0.83 | KDM1A (0.53) | KDM1AEHMT2ALDH1A1MAPK1RAD52 | |
| SCHEMBL14585295 | 0.83 | KDM1A (0.55) | KDM1AEHMT2ALDH1A1MAPK1RAD52 | |
| SCHEMBL4631081 | 0.83 | KDM1A (0.63) | KDM1AEHMT2ALDH1A1MAPK1RAD52 | |
| SCHEMBL14585380 | 0.82 | KDM1A (0.51) | KDM1AEHMT2ALDH1A1MAPK1RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070032502-A1 | Quinazoline derivatives useful in cancer treatment | SCHERING CORPORATION | 2007-02-08 | — | — | US | disclosed |
| US-20070032502-A1 | Quinazoline derivatives useful in cancer treatment | SCHERING CORPORATION | 2007-02-08 | — | — | US | disclosed |
| WO-2007011623-A1 | QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT | SCHERING CORPORATION (US) | 2007-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032502-A1 | Quinazoline derivatives useful in cancer treatment | TP53, ACIN1, TP53BP1 | KDM1A 1966/4885EHMT2 3519/4885ACP1 2019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.