SCHEMBL14586296

SCHEMBL14586296

CC1(C)Oc2cccc([Si](C)(C)CCl)c2O1

nearest known ligand 0.39

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.39
TSHR P16473 1/20 0.33
CCR8 P51685 1/20 0.30
KCNH2 Q12809 1/20 0.30
MAPK1 P28482 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25844904 0.74 ALDH1A1 (0.42) ALDH1A1TSHRCCR8KCNH2MAPK1
SCHEMBL11021936 0.71 AHR (0.45) ALDH1A1TSHR
SCHEMBL16573103 0.69 ALDH1A1 (0.44) ALDH1A1TSHR
SCHEMBL10522329 0.69 ALDH1A1 (0.46) ALDH1A1TSHR
SCHEMBL12681552 0.68 ALDH1A1 (0.46) ALDH1A1TSHRCCR8KCNH2
SCHEMBL31474205 0.67 ALDH1A1 (0.45) ALDH1A1TSHRKCNH2
SCHEMBL3156898 0.67 ALDH1A1 (0.49) ALDH1A1TSHRCCR8KCNH2
SCHEMBL18866953 0.67 ALDH1A1 (0.45) ALDH1A1TSHRCCR8KCNH2
SCHEMBL11435846 0.67 ALDH1A1 (0.45) ALDH1A1TSHR
SCHEMBL15721688 0.67 ALDH1A1 (0.45) ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7179932-B2 Synthesis of cis-diols from aryl silanes GENENCOR INTERNATIONAL, INC. (US) 2007-02-20 US disclosed