Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | CDK2 | P24941 | 11/20 | 0.61 |
| ▸ | CCNE2 | O96020 | 8/20 | 0.61 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.61 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.61 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.61 |
| ▸ | CDK1 | P06493 | 8/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.56 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.56 |
| ▸ | CLK2 | P49760 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.56 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.56 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5470136 | 0.91 | TDP1 (0.76) | TDP1CDK2CCNE2CCNE1CDK1 | |
| SCHEMBL14587742 | 0.82 | TDP1 (0.67) | TDP1KDM4ENPC1MAPTCDK2 | |
| SCHEMBL14587740 | 0.81 | TDP1 (0.57) | TDP1KDM4ENPC1MAPTCDK2 | |
| SCHEMBL14587746 | 0.80 | CDK1 (0.57) | TDP1KDM4ENPC1MAPTCDK2 | |
| SCHEMBL14587743 | 0.79 | CDK1 (0.85) | KDM4EMAPTCDK2CCNE1CDK1 | |
| SCHEMBL5466709 | 0.77 | TDP1 (0.78) | TDP1KDM4ENPC1MAPTCDK2 | |
| SCHEMBL5461238 | 0.76 | TDP1 (0.86) | TDP1CDK2CCNE2CCNE1CDK1 | |
| Myoseverin SCHEMBL13325947 | 0.76 | TDP1 (1.00) | TDP1KDM4ENPC1MAPTCDK2 | |
| Myoseverin SCHEMBL29376276 | 0.76 | TDP1 (1.00) | TDP1KDM4ENPC1MAPTCDK2 | |
| SCHEMBL14587744 | 0.75 | CDK1 (0.64) | TDP1KDM4ENPC1MAPTCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176312-B2 | Kinase inhibitor scaffolds and methods for their preparation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-02-13 | — | — | US | disclosed |