Myoseverin

Myoseverin

SCHEMBL29376276

COc1ccc(CNc2nc(NCc3ccc(OC)cc3)c3ncn(C(C)C)c3n2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 2/20 1.00
▸ CCNE2 O96020 7/20 0.86
▸ CCNE1 P24864 7/20 0.86
▸ CDK2 P24941 7/20 0.86
▸ CDK1 P06493 3/20 0.81
▸ CDK5 Q00535 6/20 0.79
▸ CDK5R1 Q15078 6/20 0.79
▸ KDM4E B2RXH2 1/20 0.74
▸ NPC1 O15118 1/20 0.74
▸ MAPT P10636 1/20 0.74
▸ CCNB2 O95067 1/20 0.73
▸ CCNB1 P14635 1/20 0.73
▸ CCNB3 Q8WWL7 1/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Myoseverin SCHEMBL13325947 1.00 TDP1 (1.00) TDP1CCNE2CCNE1CDK2CDK1
SCHEMBL13359693 0.95 TDP1 (0.90) TDP1CCNE2CCNE1CDK2CDK1
SCHEMBL5461238 0.92 TDP1 (0.86) TDP1CCNE2CCNE1CDK2CDK1
SCHEMBL1443236 0.89 TDP1 (0.80) TDP1CCNE2CCNE1CDK2CDK1
SCHEMBL4422868 0.88 CDK1 (0.81) TDP1CCNE2CCNE1CDK2CDK1
SCHEMBL14587794 0.88 TDP1 (0.78) TDP1CCNE2CCNE1CDK2CDK1
SCHEMBL4422862 0.88 CDK1 (0.81) TDP1CCNE2CCNE1CDK2CDK1
SCHEMBL5466709 0.88 TDP1 (0.78) TDP1CCNE2CCNE1CDK2CDK1
SCHEMBL1443401 0.87 CDK1 (0.85) TDP1CCNE2CCNE1CDK2CDK1
SCHEMBL5470136 0.87 TDP1 (0.76) TDP1CCNE2CCNE1CDK2CDK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250325717-A1 ANTI-NUCLEOPHOSMIN 1 ANTIBODY AND ANTIBODY CONJUGATE COMBINATION THERAPIES THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 2025-10-23 — — US claimed
US-20250313647-A1 MUTANT AND MISLOCALIZED CELL SURFACE NUCLEOPHOSMIN 1 AS A DIAGNOSTIC AND THERAPEUTIC TARGET OF HUMAN DISEASE THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 2025-10-09 — — US claimed
EP-4580677-A2 SARS-COV2 ANTIBODIES AND USES THEREOF Invivyd, Inc. (US) 2025-07-09 — — EP claimed
EP-4514858-A2 MUTANT AND MISLOCALIZED CELL SURFACE NUCLEOPHOSMIN 1 AS A DIAGNOSTIC AND THERAPEUTIC TARGET OF HUMAN DISEASE The Children's Medical Center Corporation (US) 2025-03-05 — — EP claimed
EP-4514857-A2 ANTI-NUCLEOPHOSMIN 1 ANTIBODY AND ANTIBODY CONJUGATE COMBINATION THERAPIES The Children's Medical Center Corporation (US) 2025-03-05 — — EP claimed
EP-4505179-A2 SARS-COV2 ANTIBODIES AND USES THEREOF Invivyd, Inc. (US) 2025-02-12 — — EP claimed
US-20240317892-A1 ANTI-ADAM12 ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS, AND COMPOSITIONS AND METHODS COMPRISING JAVELIN ONCOLOGY INC (US) 2024-09-26 — — US claimed
WO-2024050356-A2 SARS-COV2 ANTIBODIES AND USES THEREOF Invivyd, Inc. (US) 2024-03-07 — — WO claimed
WO-2023215746-A2 ANTI-ALPPL2 ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS, AND COMPOSITIONS AND METHODS OF USE JAVELIN ONCOLOGY, INC. (US) 2023-11-09 — — WO claimed
WO-2023212632-A2 ANTI-NUCLEOPHOSMIN 1 ANTIBODY AND ANTIBODY CONJUGATE COMBINATION THERAPIES THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 2023-11-02 — — WO claimed
WO-2023212646-A2 MUTANT AND MISLOCALIZED CELL SURFACE NUCLEOPHOSMIN 1 AS A DIAGNOSTIC AND THERAPEUTIC TARGET OF HUMAN DISEASE THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 2023-11-02 — — WO claimed
WO-2023193017-A2 SARS-COV2 ANTIBODIES AND USES THEREOF Invivyd, Inc. (US) 2023-10-05 — — WO claimed
WO-2023056429-A1 ANTI-NMDAR2B ANTIBODIES, ANTIBODY-DRUG CONJUGATES, AND CHIMERIC ANTIGEN RECEPTORS, AND COMPOSITIONS AND METHODS OF USE THE TRUSTEES OF DARTMOUTH COLLEGE (US) 2023-04-06 — — WO claimed
WO-2022170126-A2 COMPOUNDS SPECIFIC TO CORONAVIRUS S PROTEIN AND USES THEREOF ADAGIO THERAPEUTICS, INC. (US) 2022-08-11 — — WO claimed
EP-4731263-A1 BIO-CONJUGATES FOR ONCOLOGY RDP Pharma AG (CH) 2026-04-29 — — EP disclosed
US-20260103506-A1 SARS-COV2 ANTIBODIES AND METHODS OF USE THEREOF INVIVYD INC (US) 2026-04-16 — — US disclosed
US-20260078171-A1 SARS-COV2 ANTIBODIES AND USES THEREOF INVIVYD INC (US) 2026-03-19 — — US disclosed
CN-114099840-A Point-of-care drug delivery devices and methods 建南德克公司 2022-03-01 — — CN disclosed
CN-107427468-B Site-specific administration of BTK inhibitors 普林斯匹亚生物制药公司 2022-02-25 — — CN disclosed
CN-114025844-A Protein tyrosine phosphatase inhibitors and methods of use thereof 卡里科生命科学有限责任公司 2022-02-08 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240317892-A1 ANTI-ADAM12 ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS, AND COMPOSITIONS AND METHODS COMPRISING ADAM12, ADAM10, ADAM17 TDP1 1103/4885CCNE2 4673/4885CCNE1 4387/4885
US-20260103506-A1 SARS-COV2 ANTIBODIES AND METHODS OF USE THEREOF IGLV6-57, IGSF11, VSIG8 TDP1 3791/4885CCNE2 4118/4885CCNE1 4313/4885
US-20260078171-A1 SARS-COV2 ANTIBODIES AND USES THEREOF IGLV6-57, SARS1, IGSF11 TDP1 2252/4885CCNE2 3679/4885CCNE1 4064/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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