Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1460134 | 0.86 | CNR2 (0.46) | RAB9ANPC1FAAHSMO | |
| SCHEMBL1458906 | 0.79 | RAB9A (0.42) | RAB9ANPC1ALDH1A1HSD17B10L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL14716442 | 0.77 | SMO (0.57) | ALDH1A1L3MBTL1HTTSMN1; SMN2MAPT | |
| SCHEMBL1458341 | 0.75 | RAB9A (0.53) | RAB9ANPC1ALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL14716261 | 0.71 | SMO (0.65) | RAB9ANPC1ALDH1A1FAAHHTT | |
| SCHEMBL1460137 | 0.68 | CNR2 (0.41) | RAB9ANPC1FAAH | |
| SCHEMBL11071836 | 0.66 | RAB9A (1.00) | RAB9ANPC1ALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL11068640 | 0.65 | RAB9A (0.78) | RAB9ANPC1ALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL11065477 | 0.64 | RAB9A (0.80) | RAB9ANPC1ALDH1A1HSD17B10L3MBTL1 | |
| Hydrochloric Acid SCHEMBL1458339 | 0.64 | KDM4E (0.54) | RAB9ANPC1ALDH1A1HSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130053396-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.R.L. (IT) | 2013-02-28 | — | — | US | claimed |
| EP-2480543-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | Istituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L. (IT) | 2012-08-01 | — | — | EP | claimed |
| WO-2011036478-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2011-03-31 | — | — | WO | claimed |
| US-20130053396-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.R.L. (IT) | 2013-02-28 | — | — | US | disclosed |
| EP-2480543-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | Istituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L. (IT) | 2012-08-01 | — | — | EP | disclosed |
| WO-2011036478-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2011-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053396-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | SHH, SMO, GLI1 | RAB9A 1472/4885NPC1 2969/4885ALDH1A1 876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.