Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMO | Q99835 | 6/20 | 0.39 |
| ▸ | FAAH | O00519 | 10/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1458902 | 0.86 | RAB9A (0.48) | NPC1RAB9ASMOFAAH | |
| SCHEMBL1460137 | 0.78 | CNR2 (0.41) | CNR2NPC1RAB9AFAAH | |
| Trifluoroacetic Acid SCHEMBL14716245 | 0.77 | SMO (0.61) | NPC1RAB9ASMOFAAH | |
| SCHEMBL1458340 | 0.76 | FAAH (0.51) | NPC1RAB9AFAAH | |
| SCHEMBL14716258 | 0.71 | SMO (0.69) | NPC1RAB9ASMOFAAH | |
| SCHEMBL1458906 | 0.69 | RAB9A (0.42) | NPC1RAB9AFAAH | |
| Hydrochloric Acid SCHEMBL1458346 | 0.65 | KDM4E (0.52) | NPC1RAB9A | |
| SCHEMBL3084495 | 0.63 | CNR2 (1.00) | CNR2NPC1RAB9AFAAH | |
| Trifluoroacetic Acid SCHEMBL2158204 | 0.63 | SMO (0.90) | SMO | |
| Trifluoroacetic Acid SCHEMBL14716442 | 0.63 | SMO (0.57) | CNR2SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130053396-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.R.L. (IT) | 2013-02-28 | — | — | US | claimed |
| EP-2480543-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | Istituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L. (IT) | 2012-08-01 | — | — | EP | claimed |
| WO-2011036478-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2011-03-31 | — | — | WO | claimed |
| US-20130053396-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.R.L. (IT) | 2013-02-28 | — | — | US | disclosed |
| EP-2480543-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | Istituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L. (IT) | 2012-08-01 | — | — | EP | disclosed |
| WO-2011036478-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2011-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053396-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | SHH, SMO, GLI1 | CNR2 1125/4885NPC1 2969/4885RAB9A 1472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.