Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.64 |
| ▸ | GAA | P10253 | 5/20 | 0.64 |
| ▸ | GLA | P06280 | 3/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | CASP1 | P29466 | 2/20 | 0.50 |
| ▸ | CASP7 | P55210 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.50 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.50 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.50 |
| ▸ | EP300 | Q09472 | 1/20 | 0.47 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.47 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21801051 | 0.83 | KDM4E (0.53) | ALDH1A1KDM4EGAAGLAHSD17B10 | |
| SCHEMBL21801064 | 0.81 | KDM4E (0.51) | ALDH1A1KDM4EGAAGLAHSD17B10 | |
| SCHEMBL28892677 | 0.81 | KDM4E (0.51) | ALDH1A1KDM4EGAAGLAHSD17B10 | |
| SCHEMBL28892356 | 0.81 | KDM4E (0.51) | ALDH1A1KDM4EGAAGLAHSD17B10 | |
| SCHEMBL30757324 | 0.81 | KDM4E (0.51) | ALDH1A1KDM4EGAAGLAHSD17B10 | |
| SCHEMBL14589054 | 0.80 | KDM4E (0.59) | ALDH1A1KDM4EGAAGLAHTT | |
| SCHEMBL1062129 | 0.78 | ALDH1A1 (0.74) | ALDH1A1KDM4EGAAGLAHSD17B10 | |
| SCHEMBL31758437 | 0.78 | ALDH1A1 (0.61) | ALDH1A1KDM4EGAAGLAHSD17B10 | |
| SCHEMBL30419031 | 0.78 | ALDH1A1 (0.74) | ALDH1A1KDM4EGAAGLAHSD17B10 | |
| SCHEMBL29464551 | 0.78 | ALDH1A1 (1.00) | ALDH1A1KDM4EGAAGLAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7183411-B2 | Naphthol, quinoline and isoquinoline-derived urea modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-02-27 | — | — | US | disclosed |
| US-7183411-B2 | Naphthol, quinoline and isoquinoline-derived urea modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-02-27 | — | — | US | disclosed |