Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | CLK3 | P49761 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5657172 | 0.81 | RXFP1 (0.64) | CHUKRXFP1EGFRKMT2AMEN1 | |
| SCHEMBL5657826 | 0.79 | RXFP1 (0.45) | CHUKRXFP1KMT2AMEN1KDM4E | |
| SCHEMBL4021056 | 0.78 | EP300 (0.51) | CHUKRXFP1KMT2AMEN1KDM4E | |
| SCHEMBL4020385 | 0.74 | KMT2A (0.55) | CHUKKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL16508198 | 0.71 | CASP6 (0.44) | CHUKRXFP1KMT2AMEN1KDM4E | |
| SCHEMBL25899546 | 0.71 | CHUK (0.43) | CHUKRXFP1EGFRKMT2AMEN1 | |
| SCHEMBL9651248 | 0.70 | MEN1 (0.53) | KMT2AMEN1KDM4EMAPTALDH1A1 | |
| SCHEMBL4023574 | 0.70 | MAPT (0.62) | KMT2AMEN1KDM4EMAPTALDH1A1 | |
| SCHEMBL30645377 | 0.70 | MEN1 (0.53) | KMT2AMEN1KDM4EMAPTALDH1A1 | |
| SCHEMBL12277695 | 0.69 | MAPT (0.50) | CHUKMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7183411-B2 | Naphthol, quinoline and isoquinoline-derived urea modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-02-27 | — | — | US | disclosed |
| US-7183411-B2 | Naphthol, quinoline and isoquinoline-derived urea modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-02-27 | — | — | US | disclosed |