Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2624486 | 0.89 | SIRT1 (0.49) | MAPTPOLBTP53RXFP1ALDH1A1 | |
| SCHEMBL14620812 | 0.80 | NPC1 (0.45) | MAPTPOLBTP53RXFP1ALDH1A1 | |
| SCHEMBL2740122 | 0.77 | TP53 (0.51) | MAPTPOLBTP53RXFP1ALDH1A1 | |
| SCHEMBL2740129 | 0.74 | KDM4E (0.49) | MAPTPOLBTP53RXFP1ALDH1A1 | |
| SCHEMBL10282658 | 0.73 | KDM4E (0.48) | MAPTTP53RXFP1ALDH1A1KDM4E | |
| SCHEMBL2740135 | 0.73 | SLC40A1 (0.48) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL5044200 | 0.73 | SIRT1 (0.51) | MAPTPOLBTP53RXFP1ALDH1A1 | |
| SCHEMBL2740223 | 0.72 | MAPT (0.59) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL5045034 | 0.72 | KDM4E (0.49) | MAPTPOLBALDH1A1KDM4EMEN1 | |
| SCHEMBL5020212 | 0.72 | SLC40A1 (0.56) | MAPTTP53RXFP1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070043050-A1 | Sirtuin modulating compounds | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043050-A1 | Sirtuin modulating compounds | SIRT1, SIRT3, SIRT2 | MAPT 744/4885POLB 2253/4885TP53 861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.