SCHEMBL1458950

SCHEMBL1458950

CCC(=O)N(c1ccccc1)c1nccs1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.57
TRPM8 Q7Z2W7 2/20 0.43
FFAR1 O14842 1/20 0.42
FFAR4 Q5NUL3 1/20 0.42
SENP8 Q96LD8 1/20 0.41
SENP7 Q9BQF6 1/20 0.41
SENP6 Q9GZR1 1/20 0.41
KMT2A Q03164 3/20 0.40
POLB P06746 2/20 0.40
NPSR1 Q6W5P4 2/20 0.40
NPC1 O15118 1/20 0.40
ALDH1A1 P00352 1/20 0.40
HTT P42858 1/20 0.40
RAB9A P51151 1/20 0.40
MEN1 O00255 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
ALOX15 P16050 1/20 0.39
MAPK1 P28482 1/20 0.39
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18939373 0.89 LMNA (0.55) LMNATRPM8FFAR1FFAR4KMT2A
SCHEMBL18939561 0.86 LMNA (0.53) LMNATRPM8FFAR1FFAR4KMT2A
SCHEMBL2772989 0.83 LMNA (0.51) LMNATRPM8FFAR1FFAR4KMT2A
SCHEMBL22074395 0.83 TRPM8 (0.53) LMNATRPM8FFAR1FFAR4SENP8
SCHEMBL1896858 0.83 LMNA (0.53) LMNATRPM8FFAR1FFAR4KMT2A
SCHEMBL2772986 0.80 LMNA (0.51) LMNATRPM8FFAR1FFAR4KMT2A
SCHEMBL1325354 0.80 LMNA (0.51) LMNATRPM8FFAR1FFAR4KMT2A
SCHEMBL28977221 0.79 LMNA (0.48) LMNATRPM8FFAR1FFAR4KMT2A
SCHEMBL17439454 0.79 LMNA (0.48) LMNATRPM8FFAR1FFAR4KMT2A
SCHEMBL22074409 0.79 TRPM8 (0.61) LMNATRPM8SENP8SENP7SENP6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2483280-A1 NEW AMINOACID DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS INHIBITORS OF ONCOGENIC SIGNALS BY THE MET FAMILY Université d'Aix-Marseille (FR) 2012-08-08 EP claimed
EP-2305688-A1 Novel aminoacids derivatives, their process of preparation and their therapeutical uses as MET inhibitors Université de la Méditerranée - Aix-Marseille II (FR) 2011-04-06 EP claimed
WO-2011036303-A1 NEW AMINOACID DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS INHIBITORS OF ONCOGENIC SIGNALS BY THE MET FAMILY UNIVERSITE DE LA MEDITERRANEE AIX-MARSEILLE II (FR) 2011-03-31 WO claimed
EP-2483280-A1 NEW AMINOACID DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS INHIBITORS OF ONCOGENIC SIGNALS BY THE MET FAMILY Université d'Aix-Marseille (FR) 2012-08-08 EP disclosed
EP-2305688-A1 Novel aminoacids derivatives, their process of preparation and their therapeutical uses as MET inhibitors Université de la Méditerranée - Aix-Marseille II (FR) 2011-04-06 EP disclosed
WO-2011036303-A1 NEW AMINOACID DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS INHIBITORS OF ONCOGENIC SIGNALS BY THE MET FAMILY UNIVERSITE DE LA MEDITERRANEE AIX-MARSEILLE II (FR) 2011-03-31 WO disclosed