Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.74 |
| ▸ | KDR | P35968 | 2/20 | 0.74 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.74 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.74 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.74 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.74 |
| ▸ | LTK | P29376 | 1/20 | 0.74 |
| ▸ | GRK5 | P34947 | 1/20 | 0.74 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.74 |
| ▸ | CDK8 | P49336 | 1/20 | 0.74 |
| ▸ | CDK7 | P50613 | 1/20 | 0.74 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.74 |
| ▸ | NEK4 | P51957 | 1/20 | 0.74 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.74 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.74 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.74 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.74 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.74 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.74 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2101550 | 0.90 | EGFR (0.76) | EGFRKDRCLK4DYRK3MAP4K4 | |
| SCHEMBL18292473 | 0.87 | EGFR (0.84) | EGFRKDRCLK4DYRK3MAP4K4 | |
| SCHEMBL8871863 | 0.86 | EGFR (0.82) | EGFRNCOA1NCOA3HTTLMNA | |
| SCHEMBL28475137 | 0.86 | EGFR (0.73) | EGFRKDRCLK4DYRK3MAP4K4 | |
| SCHEMBL15503743 | 0.85 | NCOA1 (1.00) | EGFRKDRNCOA1NCOA3HTT | |
| SCHEMBL9017043 | 0.85 | EGFR (1.00) | EGFRKDRCLK4DYRK3MAP4K4 | |
| SCHEMBL6664796 | 0.83 | HTT (0.67) | EGFRKDRCLK4DYRK3MAP4K4 | |
| SCHEMBL5474772 | 0.83 | KDR (1.00) | EGFRKDRMAPK14ABCG2LMNA | |
| SCHEMBL2101381 | 0.82 | HTT (1.00) | EGFRKDRCLK4MAP4K4LTK | |
| SCHEMBL8871268 | 0.82 | EGFR (0.76) | EGFRKDRCLK4DYRK3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070060582-A1 | 1,4-Disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases | FINK CYNTHIA A | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060582-A1 | 1,4-Disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases | BRAF, RAF1, NRAS | EGFR 255/4885KDR 1189/4885CLK4 2067/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.