SCHEMBL1459528

SCHEMBL1459528

COC(=O)c1cccc(Nc2ccc(-c3ccc(Nc4cccc(C(=O)OC)c4)cc3)cc2)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.58
POLB P06746 1/20 0.58
ALDH1A1 P00352 1/20 0.56
NPC1 O15118 3/20 0.56
MAPT P10636 3/20 0.56
MEN1 O00255 1/20 0.55
CYP1A2 P05177 1/20 0.55
CYP3A4 P08684 1/20 0.55
CYP2D6 P10635 1/20 0.55
CYP2C9 P11712 1/20 0.55
CYP2C19 P33261 1/20 0.55
KMT2A Q03164 1/20 0.55
TP53 P04637 2/20 0.55
LMNA P02545 2/20 0.55
PLAU P00749 2/20 0.55
TSHR P16473 1/20 0.55
MAPK1 P28482 1/20 0.55
ROCK1 Q13464 1/20 0.53
PDE5A O76074 1/20 0.53
PTPN1 P18031 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1745412 0.90 RAB9A (0.71) RAB9APOLBALDH1A1NPC1MAPT
SCHEMBL13465148 0.89 TCF4 (0.63) RAB9APOLBALDH1A1NPC1MAPT
SCHEMBL29818113 0.88 ROCK1 (0.56) RAB9APOLBALDH1A1NPC1MAPT
SCHEMBL13465390 0.87 RAB9A (0.55) RAB9APOLBALDH1A1NPC1MAPT
SCHEMBL22453217 0.87 RAB9A (0.59) RAB9APOLBALDH1A1NPC1MAPT
SCHEMBL5928165 0.87 TCF4 (0.64) RAB9APOLBALDH1A1NPC1MAPT
SCHEMBL5928751 0.87 RAB9A (0.74) RAB9APOLBALDH1A1NPC1MAPT
SCHEMBL13465147 0.87 RAB9A (0.55) RAB9APOLBALDH1A1NPC1MAPT
SCHEMBL9560810 0.87 MEN1 (0.57) RAB9APOLBALDH1A1NPC1MAPT
SCHEMBL27928486 0.87 ROCK1 (0.58) RAB9APOLBALDH1A1NPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1407500-B1 ELECTROACTIVE POLYMERS AND DEVICES MADE THEREFROM DOW GLOBAL TECHNOLOGIES INC (US) 2008-11-12 EP claimed
US-20030045642-A1 Reacting aromatic or heteroaromatic monomers to build indivisual blocks separately, followed by combining indivisual blocks to form a single component block polymer DEPARTMENT OF THE NAVY 2003-03-06 US claimed
EP-1921688-B1 Electroactive polymers and devices made therefrom DOW GLOBAL TECHNOLOGIES INC (US) 2011-03-30 EP disclosed
EP-2262021-A1 Electroactive polymers and devices made therefrom DOW GLOBAL TECHNOLOGIES INC. (US) 2010-12-15 EP disclosed
EP-2262022-A1 Electroactive polymers and devices made therefrom DOW GLOBAL TECHNOLOGIES INC. (US) 2010-12-15 EP disclosed
EP-1407500-B1 ELECTROACTIVE POLYMERS AND DEVICES MADE THEREFROM DOW GLOBAL TECHNOLOGIES INC (US) 2008-11-12 EP disclosed
EP-1921688-A2 Electroactive polymers and devices made therefrom Dow Gloval Technologies Inc. (US) 2008-05-14 EP disclosed
US-6815505-B2 REACTING AROMATIC OR HETEROAROMATIC MONOMERS TO BUILD INDIVISUAL BLOCKS SEPARATELY, FOLLOWED BY COMBINING INDIVISUAL BLOCKS TO FORM A SINGLE COMPONENT BLOCK POLYMER DOW GLOBAL TECHNOLOGIES INC. 2004-11-09 US disclosed
EP-1407500-A1 ELECTROACTIVE POLYMERS AND DEVICES MADE THEREFROM DOW GLOBAL TECHNOLOGIES INC. (US) 2004-04-14 EP disclosed
US-20030045642-A1 Reacting aromatic or heteroaromatic monomers to build indivisual blocks separately, followed by combining indivisual blocks to form a single component block polymer DEPARTMENT OF THE NAVY 2003-03-06 US disclosed
WO-2003007395-A1 ELECTROACTIVE POLYMERS AND DEVICES MADE THEREFROM DOW GLOBAL TECHNOLOGIES INC. (US) 2003-01-23 WO disclosed