Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 6/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14868617 | 0.92 | ALDH1A1 (0.48) | KMT2AGAAALDH1A1MAPTMEN1 | |
| SCHEMBL10591725 | 0.82 | KMT2A (0.65) | KMT2AGAAALDH1A1MAPTMEN1 | |
| SCHEMBL6695378 | 0.79 | KMT2A (0.53) | KMT2AGAAALDH1A1MAPTMEN1 | |
| SCHEMBL13584238 | 0.79 | ALDH1A1 (0.46) | KMT2AGAAALDH1A1MAPTMEN1 | |
| SCHEMBL2755805 | 0.79 | EPHX2 (0.68) | KMT2AGAAALDH1A1MAPTMEN1 | |
| SCHEMBL11597341 | 0.79 | KMT2A (0.70) | KMT2AGAAALDH1A1MAPTMEN1 | |
| SCHEMBL31284342 | 0.78 | KMT2A (0.48) | KMT2AGAAALDH1A1MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL8129113 | 0.78 | KMT2A (0.51) | KMT2AGAAALDH1A1MAPTMEN1 | |
| SCHEMBL10310225 | 0.78 | KMT2A (0.59) | KMT2AGAAALDH1A1MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL13584105 | 0.78 | ALDH1A1 (0.44) | KMT2AGAAALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070060582-A1 | 1,4-Disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases | FINK CYNTHIA A | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060582-A1 | 1,4-Disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases | BRAF, RAF1, NRAS | KMT2A 1581/4885GAA 3215/4885ALDH1A1 1890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.