Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.39 |
| ▸ | ADH1B | P00325 | 2/20 | 0.37 |
| ▸ | ADH1C | P00326 | 2/20 | 0.37 |
| ▸ | ADH1A | P07327 | 2/20 | 0.37 |
| ▸ | ADH7 | P40394 | 2/20 | 0.37 |
| ▸ | ADH4 | P08319 | 1/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL1458552 | 1.00 | OPRM1 (0.58) | OPRM1TP53TSHRALDH1A1ANPEP | |
| Lithium Ion SCHEMBL12983285 | 0.98 | OPRM1 (0.60) | OPRM1TP53TSHRALDH1A1ANPEP | |
| Lithium Ion SCHEMBL1459206 | 0.96 | OPRM1 (0.64) | OPRM1TP53TSHRALDH1A1ANPEP | |
| Lithium Ion SCHEMBL1459203 | 0.94 | OPRM1 (0.67) | OPRM1TP53TSHRALDH1A1ANPEP | |
| Lithium Ion SCHEMBL1459218 | 0.92 | OPRM1 (0.52) | OPRM1TP53TSHRALDH1A1ANPEP | |
| Lithium Ion SCHEMBL12984584 | 0.92 | OPRM1 (0.52) | OPRM1TP53TSHRALDH1A1ANPEP | |
| Lithium Ion SCHEMBL1458572 | 0.92 | OPRM1 (0.52) | OPRM1TP53TSHRALDH1A1ANPEP | |
| SCHEMBL21900855 | 0.92 | OPRM1 (0.70) | OPRM1TP53TSHRALDH1A1ANPEP | |
| SCHEMBL17728271 | 0.92 | OPRM1 (0.70) | OPRM1TP53TSHRALDH1A1ANPEP | |
| Lithium Ion SCHEMBL1460434 | 0.92 | OPRM1 (0.56) | OPRM1TP53TSHRALDH1A1ANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475534-A1 | COMPOSITIONS AND METHODS FOR PRODUCING POLY-AMINOFUNCTIONALIZED POLYMERIZATION INITIATORS AND CORRESPONDING POLYMERS | Bridgestone Corporation (JP) | 2012-07-18 | — | — | EP | disclosed |
| WO-2011031943-A1 | COMPOSITIONS AND METHODS FOR PRODUCING POLY-AMINOFUNCTIONALIZED POLYMERIZATION INITIATORS AND CORRESPONDING POLYMERS | BRIDGESTONE CORPORATION (JP) | 2011-03-17 | — | — | WO | disclosed |