Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 2/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | ADH1B | P00325 | 1/20 | 0.33 |
| ▸ | ADH1C | P00326 | 1/20 | 0.33 |
| ▸ | ADH1A | P07327 | 1/20 | 0.33 |
| ▸ | ADH4 | P08319 | 1/20 | 0.33 |
| ▸ | ADH7 | P40394 | 1/20 | 0.33 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL1458572 | 1.00 | OPRM1 (0.52) | OPRM1TP53ALDH1A1TSHRPAOX | |
| Lithium Ion SCHEMBL1459218 | 1.00 | OPRM1 (0.52) | OPRM1TP53ALDH1A1TSHRPAOX | |
| Lithium Ion SCHEMBL1459212 | 0.98 | OPRM1 (0.54) | OPRM1TP53ALDH1A1TSHRPAOX | |
| Lithium Ion SCHEMBL1459206 | 0.92 | OPRM1 (0.64) | OPRM1TP53ALDH1A1TSHRANPEP | |
| Lithium Ion SCHEMBL1458552 | 0.92 | OPRM1 (0.58) | OPRM1TP53ALDH1A1TSHRANPEP | |
| Lithium Ion SCHEMBL1459593 | 0.92 | OPRM1 (0.58) | OPRM1TP53ALDH1A1TSHRANPEP | |
| Lithium Ion SCHEMBL1459566 | 0.92 | OPRM1 (0.50) | OPRM1TP53ALDH1A1TSHRPAOX | |
| Lithium Ion SCHEMBL1459203 | 0.90 | OPRM1 (0.67) | OPRM1TP53ALDH1A1TSHRANPEP | |
| Lithium Ion SCHEMBL12983285 | 0.90 | OPRM1 (0.60) | OPRM1TP53ALDH1A1TSHRANPEP | |
| SCHEMBL21900855 | 0.88 | OPRM1 (0.70) | OPRM1TP53ALDH1A1TSHRANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8729204-B2 | Compositions and method for producing poly-aminofunctionalized polymerization initiators and corresponding polymers | BRIDGESTONE CORPORATION (JP) | 2014-05-20 | — | — | US | disclosed |
| EP-2475534-B1 | COMPOSITIONS AND METHODS FOR PRODUCING POLY-AMINOFUNCTIONALIZED POLYMERIZATION INITIATORS AND CORRESPONDING POLYMERS | BRIDGESTONE CORP (JP) | 2013-10-23 | — | — | EP | disclosed |
| US-20120259056-A1 | COMPOSITIONS AND METHOD FOR PRODUCING POLY-AMINOFUNCTIONALIZED POLYMERIZATION INITIATORS AND CORRESPONDING POLYMERS | BRIDGESTONE CORPORATION (JP) | 2012-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120259056-A1 | COMPOSITIONS AND METHOD FOR PRODUCING POLY-AMINOFUNCTIONALIZED POLYMERIZATION INITIATORS AND CORRESPONDING POLYMERS | PARG, PARN, PAM | OPRM1 2356/4885TP53 3609/4885ALDH1A1 2840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.