Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.60 |
| ▸ | CA2 | P00918 | 6/20 | 0.60 |
| ▸ | CA9 | Q16790 | 6/20 | 0.60 |
| ▸ | CA12 | O43570 | 5/20 | 0.60 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 12/20 | 0.49 |
| ▸ | HTR1D | P28221 | 12/20 | 0.49 |
| ▸ | HTR1B | P28222 | 12/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.48 |
| ▸ | HTR2C | P28335 | 4/20 | 0.48 |
| ▸ | HTR6 | P50406 | 4/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.46 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5452315 | 0.91 | HTR1A (0.49) | CA1CA2CA9CA12HTR1A | |
| SCHEMBL14596943 | 0.90 | HTR1A (0.49) | CA1CA2CA9CA12HTR1A | |
| SCHEMBL14596946 | 0.88 | HTR1A (0.47) | CA1CA2CA9CA12HTR1A | |
| SCHEMBL14596964 | 0.88 | HTR1A (0.49) | CA1CA2CA9CA12HTR1A | |
| SCHEMBL14596944 | 0.88 | HTR1A (0.47) | CA1CA2CA9CA12HTR1A | |
| SCHEMBL14596950 | 0.88 | HTR1A (0.47) | CA1CA2CA9CA12HTR1A | |
| SCHEMBL14596940 | 0.88 | HTR1A (0.49) | CA1CA2CA9CA12HTR1A | |
| SCHEMBL14596942 | 0.88 | HTR1A (0.47) | CA1CA2CA9CA12HTR1A | |
| SCHEMBL14596986 | 0.88 | HTR1A (0.60) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL14596931 | 0.87 | LMNA (0.57) | CA1CA2CA9CA12PTPN7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010526-A1 | Therapeutic isoquinoline compounds | ASTRAZENECA AB (SE) | 2007-01-11 | — | — | US | disclosed |
| US-20070010526-A1 | Therapeutic isoquinoline compounds | ASTRAZENECA AB (SE) | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010526-A1 | Therapeutic isoquinoline compounds | HTR1B, HTR1D, HTR1A | CA1 3416/4885CA2 4522/4885CA9 4511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.