Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.57 |
| ▸ | KLF10 | Q13118 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 3/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | ESRRG | P62508 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6644245 | 0.88 | ALDH1A1 (0.59) | ESR1ALOX15APPALDH1A1HPGD | |
| SCHEMBL13320847 | 0.81 | ESR1 (0.46) | ESR1KLF10ALOX15APPRORC | |
| SCHEMBL1501111 | 0.75 | ALDH1A1 (0.73) | ESR1KLF10ALOX15ALOX12APP | |
| SCHEMBL29360146 | 0.73 | ESR1 (1.00) | ESR1KLF10ALOX15ALOX12RORC | |
| SCHEMBL9079910 | 0.73 | ALDH1A1 (0.61) | ESR1ALOX15APPALDH1A1HPGD | |
| SCHEMBL5674836 | 0.73 | ALDH1A1 (0.70) | ESR1KLF10ALOX15ALOX12APP | |
| SCHEMBL29350788 | 0.73 | ESR1 (1.00) | ESR1KLF10ALOX15ALOX12RORC | |
| SCHEMBL35285 | 0.73 | ESR1 (1.00) | ESR1KLF10ALOX15ALOX12RORC | |
| SCHEMBL636392 | 0.71 | TRPA1 (0.54) | ESR1ALOX15ALOX12APPALDH1A1 | |
| SCHEMBL31158047 | 0.71 | TRPA1 (0.54) | ESR1ALOX15ALOX12APPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070021496-A1 | Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass | MIGENIX CORP. (US) | 2007-01-25 | — | — | US | disclosed |
| US-20070021496-A1 | Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass | MIGENIX CORP. (US) | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021496-A1 | Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass | CKMT1A; CKMT1B, ATP5F1D, MT-ATP6 | ESR1 4115/4885KLF10 3331/4885ALOX15 1724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.