Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 6/20 | 0.66 |
| ▸ | AR | P10275 | 6/20 | 0.66 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.66 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20554 | 0.84 | PGR (0.58) | PGRARNR3C2NR3C1ALDH1A1 | |
| Eplerenone SCHEMBL13061287 | 0.79 | NR3C1 (1.00) | PGRARNR3C2NR3C1ALDH1A1 | |
| Eplerenone SCHEMBL21515 | 0.79 | NR3C1 (1.00) | PGRARNR3C2NR3C1ALDH1A1 | |
| Eplerenone SCHEMBL14567731 | 0.79 | NR3C1 (1.00) | PGRARNR3C2NR3C1ALDH1A1 | |
| Eplerenone SCHEMBL14308852 | 0.79 | NR3C1 (1.00) | PGRARNR3C2NR3C1ALDH1A1 | |
| Eplerenone SCHEMBL13007056 | 0.79 | NR3C1 (1.00) | PGRARNR3C2NR3C1ALDH1A1 | |
| Eplerenone SCHEMBL16144481 | 0.79 | NR3C1 (1.00) | PGRARNR3C2NR3C1ALDH1A1 | |
| Eplerenone SCHEMBL1818157 | 0.79 | NR3C1 (1.00) | PGRARNR3C2NR3C1ALDH1A1 | |
| Eplerenone SCHEMBL14284960 | 0.79 | NR3C1 (1.00) | PGRARNR3C2NR3C1ALDH1A1 | |
| Eplerenone SCHEMBL19891818 | 0.79 | NR3C1 (1.00) | PGRARNR3C2NR3C1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7157101-B2 | Micronized eplerenone compositions | G.D. SEARLE, LLC (US) | 2007-01-02 | — | — | US | disclosed |