Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.61 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.61 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | TSHR | P16473 | 4/20 | 0.60 |
| ▸ | CES2 | O00748 | 1/20 | 0.59 |
| ▸ | CES1 | P23141 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2227754 | 0.85 | PRSS1 (0.63) | PRSS1PRSS2PRSS3ALDH1A1TSHR | |
| SCHEMBL3551362 | 0.83 | PRSS1 (0.66) | PRSS1PRSS2PRSS3ALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL4399781 | 0.82 | PRSS1 (0.69) | PRSS1PRSS2PRSS3ALDH1A1TSHR | |
| SCHEMBL4500365 | 0.81 | KMT2A (0.69) | ALDH1A1TSHRCES2CES1TP53 | |
| SCHEMBL24933536 | 0.80 | ALDH1A1 (0.64) | PRSS1PRSS2PRSS3ALDH1A1TSHR | |
| SCHEMBL2762350 | 0.77 | PRSS1 (0.96) | PRSS1PRSS2PRSS3ALDH1A1TSHR | |
| SCHEMBL2892439 | 0.77 | ALDH1A1 (0.71) | PRSS1PRSS2PRSS3ALDH1A1TSHR | |
| SCHEMBL3414390 | 0.77 | PRSS1 (0.61) | PRSS1PRSS2PRSS3ALDH1A1TSHR | |
| SCHEMBL4092998 | 0.76 | CES2 (0.74) | PRSS1PRSS2PRSS3ALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL1262882 | 0.76 | PRSS1 (1.00) | PRSS1PRSS2PRSS3ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070021483-A1 | Amidine derivatives for treating amyloidosis | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021483-A1 | Amidine derivatives for treating amyloidosis | APP, IAPP, GRN | PRSS1 2062/4885PRSS2 1749/4885PRSS3 1961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.