SCHEMBL14599686

SCHEMBL14599686

Fc1ccc(-c2c3nc(c(C#Cc4ccccn4)c4ccc([nH]4)c(C#Cc4ccccn4)c4nc(c(C#Cc5ccccn5)c5ccc2s5)C=C4)C=C3)cc1

nearest known ligand 0.36

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 1/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ ADK P55263 1/20 0.33
▸ MAPK14 Q16539 2/20 0.32
▸ TOP1 P11387 2/20 0.32
▸ GRM5 P41594 2/20 0.31
▸ TERT O14746 1/20 0.31
▸ CYCS P99999 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14629725 0.93 TDP1 (0.34) TDP1L3MBTL1ADKMAPK14TOP1
SCHEMBL14599679 0.90 STAT3 (0.39) TDP1L3MBTL1TOP1GRM5TERT
SCHEMBL14599698 0.81 FFAR1 (0.39) TDP1L3MBTL1TOP1CYCS
SCHEMBL14599677 0.79 L3MBTL1 (0.38) TDP1L3MBTL1
SCHEMBL14629726 0.70 TERT (0.40) TOP1TERTCYCS
SCHEMBL9588215 0.70 TOP1 (0.48) MAPK14TOP1TERTCYCS
SCHEMBL14599687 0.69 TOP1 (0.39) TOP1TERTCYCS
SCHEMBL14629734 0.69 STAT3 (0.43) TOP1TERTCYCS
SCHEMBL30092778 0.66 TOP1 (0.60) TOP1TERTCYCS
SCHEMBL10592809 0.66 TOP1 (0.60) TOP1TERTCYCS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070015742-A1 Porphyrin derivatives YAHIOGLU GOKHAN 2007-01-18 — — US disclosed
US-20070015742-A1 Porphyrin derivatives YAHIOGLU GOKHAN 2007-01-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070015742-A1 Porphyrin derivatives SCO2, CBR3, CBR1 TDP1 4330/4885L3MBTL1 3006/4885ADK 4761/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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