Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 17/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 17/20 | 0.44 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | IL1B | P01584 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
| ▸ | HTR3B | O95264 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.34 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13464214 | 0.88 | DDB1 (0.43) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL10074225 | 0.85 | DDB1 (0.61) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL23575795 | 0.82 | DDB1 (0.44) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL7284377 | 0.80 | CRBN (0.55) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL410243 | 0.80 | CRBN (0.55) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL410700 | 0.80 | CRBN (0.55) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL442296 | 0.80 | CRBN (0.55) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL5635300 | 0.78 | DDB1 (0.73) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL29922269 | 0.78 | DDB1 (0.73) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL476975 | 0.78 | DDB1 (0.73) | DDB1CRBNIKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1767533-A1 | N-{(2-(2,6-dioxo(3-piperidyl)-1,3-dioxo-2,3-dihydro-1H-isoindolin-4-yl)methyl}cyclopropylcarboxamide as TNF inhibitor | CELGENE CORPORATION (US) | 2007-03-28 | — | — | EP | disclosed |