Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NOS2 | P35228 | 5/20 | 0.45 |
| ▸ | NOS3 | P29474 | 4/20 | 0.45 |
| ▸ | KDR | P35968 | 6/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3531199 | 0.81 | KDR (0.40) | LIMK1L3MBTL1NOS2NOS3KDR | |
| SCHEMBL31227248 | 0.77 | LIMK1 (0.34) | LIMK1L3MBTL1ROCK1 | |
| SCHEMBL3530961 | 0.76 | KDR (0.60) | LIMK1KDRAURKAAURKBEPHB4 | |
| SCHEMBL8284990 | 0.69 | KDR (0.56) | NOS2NOS3KDRAURKAAURKB | |
| SCHEMBL13764538 | 0.69 | NOS2 (0.41) | NOS2NOS3KDRAURKAAURKB | |
| SCHEMBL22171444 | 0.68 | CYP3A4 (0.46) | LIMK1L3MBTL1ABCB1 | |
| SCHEMBL1622168 | 0.67 | LIMK1 (1.00) | LIMK1L3MBTL1KDRAURKAAURKB | |
| SCHEMBL441079 | 0.65 | NOTUM (0.31) | — | |
| SCHEMBL8140505 | 0.65 | NOS2 (0.41) | NOS2NOS3KDRAURKAAURKB | |
| SCHEMBL2384277 | 0.64 | ALDH1A1 (0.33) | LIMK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7157470-B2 | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-01-02 | — | — | US | disclosed |
| US-7157470-B2 | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-01-02 | — | — | US | disclosed |