Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14602996 | 0.96 | LMNA (0.61) | LMNAHTTL3MBTL1TSHRMEN1 | |
| SCHEMBL14602994 | 0.84 | LMNA (0.64) | LMNAHTTL3MBTL1TSHRMEN1 | |
| SCHEMBL6185506 | 0.84 | LMNA (0.65) | LMNAHTTL3MBTL1TSHRMEN1 | |
| SCHEMBL14602999 | 0.84 | LMNA (0.63) | LMNAHTTL3MBTL1TSHRMEN1 | |
| SCHEMBL6186422 | 0.84 | MEN1 (0.64) | LMNAHTTL3MBTL1TSHRMEN1 | |
| SCHEMBL6187676 | 0.84 | LMNA (0.63) | LMNAHTTL3MBTL1TSHRMEN1 | |
| SCHEMBL6186883 | 0.81 | LMNA (0.59) | LMNAHTTL3MBTL1TSHRMEN1 | |
| SCHEMBL6188597 | 0.80 | TSHR (0.58) | LMNAHTTL3MBTL1TSHRMEN1 | |
| SCHEMBL591547 | 0.80 | CYP2D6 (0.74) | LMNATSHRMEN1KMT2AKDM4E | |
| SCHEMBL6185170 | 0.79 | LMNA (0.57) | LMNAHTTL3MBTL1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160879-B2 | Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1H-benzoimidazole analogues | NEUROGEN CORPORATION (US) | 2007-01-09 | — | — | US | disclosed |
| US-7160879-B2 | Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1H-benzoimidazole analogues | NEUROGEN CORPORATION (US) | 2007-01-09 | — | — | US | disclosed |