Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6187676 | 0.87 | LMNA (0.63) | LMNAHTTL3MBTL1TSHRMEN1 | |
| SCHEMBL14602994 | 0.84 | LMNA (0.64) | LMNAHTTL3MBTL1TSHRMEN1 | |
| SCHEMBL14602995 | 0.84 | LMNA (0.67) | LMNAHTTL3MBTL1TSHRMEN1 | |
| SCHEMBL14603001 | 0.83 | MEN1 (0.69) | LMNATSHRMEN1KMT2ANPSR1 | |
| SCHEMBL6186422 | 0.83 | MEN1 (0.64) | LMNAHTTL3MBTL1TSHRMEN1 | |
| SCHEMBL6185506 | 0.83 | LMNA (0.65) | LMNAHTTL3MBTL1TSHRMEN1 | |
| SCHEMBL5627072 | 0.81 | TP53 (0.52) | LMNATSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL21749173 | 0.81 | KDM4E (0.59) | L3MBTL1MEN1KMT2AGAAKDM4E | |
| SCHEMBL6185170 | 0.81 | LMNA (0.57) | LMNAHTTL3MBTL1TSHRMEN1 | |
| SCHEMBL6186764 | 0.81 | TP53 (0.64) | LMNAHTTL3MBTL1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160879-B2 | Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1H-benzoimidazole analogues | NEUROGEN CORPORATION (US) | 2007-01-09 | — | — | US | disclosed |
| US-7160879-B2 | Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1H-benzoimidazole analogues | NEUROGEN CORPORATION (US) | 2007-01-09 | — | — | US | disclosed |