Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.39 |
| ▸ | MELK | Q14680 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2382466 | 0.82 | CRBN (0.51) | KCNK3KCNK9MAPK14HPGDNPC1 | |
| SCHEMBL2380778 | 0.78 | TLK2 (0.48) | KCNK3KCNK9MAPK14HPGDNPC1 | |
| SCHEMBL2382186 | 0.78 | ESR1 (0.53) | KCNK3KCNK9MAPK14HPGDNPC1 | |
| SCHEMBL2382379 | 0.76 | NPC1 (0.58) | KCNK3KCNK9HPGDNPC1RAB9A | |
| SCHEMBL2382404 | 0.74 | NPC1 (0.60) | NPC1RAB9AKMT2A | |
| SCHEMBL12297409 | 0.72 | KCNK3 (0.57) | KCNK3KCNK9MAPK14HPGDNPC1 | |
| SCHEMBL2380902 | 0.72 | KDR (0.50) | KCNK3KCNK9MAPK14MELK | |
| SCHEMBL2380312 | 0.72 | CDK7 (0.45) | KCNK3KCNK9MAPK14HPGDNPC1 | |
| SCHEMBL2380306 | 0.71 | MAPK14 (0.49) | KCNK3KCNK9MAPK14HPGDNPC1 | |
| SCHEMBL2380402 | 0.69 | NPC1 (0.50) | KCNK3KCNK9PLAUNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070054903-A1 | Bis-aryl kinase inhibitors and method | AMGEN INC. (US) | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054903-A1 | Bis-aryl kinase inhibitors and method | HGF, MET, BLK | KCNK3 1810/4885KCNK9 2541/4885MAPK14 292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.