Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 13/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14605983 | 0.81 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL5592641 | 0.74 | HSD11B1 (0.60) | HSD11B1HDAC1HDAC6ALDH1A1TSHR | |
| SCHEMBL14605771 | 0.73 | HSD11B1 (0.57) | HSD11B1ALDH1A1TSHR | |
| SCHEMBL2591554 | 0.73 | HSD11B1 (0.57) | HSD11B1HDAC1HDAC6ALDH1A1TSHR | |
| SCHEMBL14605982 | 0.71 | HSD11B1 (0.70) | HSD11B1ALDH1A1 | |
| SCHEMBL14605742 | 0.71 | HSD11B1 (0.70) | HSD11B1ALDH1A1TSHR | |
| SCHEMBL9209430 | 0.71 | HSD11B1 (0.54) | HSD11B1HDAC1HDAC6ALDH1A1TSHR | |
| SCHEMBL9209424 | 0.71 | HSD11B1 (0.54) | HSD11B1HDAC1HDAC6ALDH1A1TSHR | |
| SCHEMBL10675890 | 0.70 | HSD11B1 (0.54) | HSD11B1HDAC1HDAC6ALDH1A1TSHR | |
| SCHEMBL12576848 | 0.69 | HSD11B1 (0.67) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007029021-A1 | 1,5-SUBSTITUTED TETRAZOLES AS THERAPEUTIC COMPOUNDS | THE UNIVERSITY OF EDINBURGH (GB) | 2007-03-15 | — | — | WO | disclosed |