Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 5/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 4/20 | 0.34 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 2/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 5/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | GRK6 | P43250 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14605892 | 0.89 | LCK (0.36) | AURKBLCKITKRETPAK1 | |
| SCHEMBL14605897 | 0.81 | LCK (0.56) | AURKBLCKITKRETPAK1 | |
| SCHEMBL5591240 | 0.79 | RET (0.40) | AURKBLCKITKRETPLK4 | |
| SCHEMBL14605903 | 0.74 | PAK1 (0.38) | AURKBLCKITKRETPAK1 | |
| SCHEMBL14605970 | 0.74 | LCK (0.57) | AURKBLCKITKRETPAK1 | |
| SCHEMBL14605945 | 0.73 | LCK (0.45) | AURKBLCKITKRETIGF1R | |
| SCHEMBL14605943 | 0.70 | PLK4 (0.38) | AURKBLCKITKRETPAK1 | |
| SCHEMBL14605899 | 0.70 | AURKB (0.54) | AURKBLCKITKRETPAK1 | |
| SCHEMBL14605960 | 0.69 | LCK (0.50) | AURKBLCKITKRETPAK1 | |
| SCHEMBL14605951 | 0.69 | LCK (0.75) | AURKBLCKITKRETPAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007023382-A2 | PYRIMIDINE AMINO PYRAZOLE COMPOUNDS, POTENT KINASE INHIBITORS | PFIZER INC. (US) | 2007-03-01 | — | — | WO | disclosed |