Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 9/20 | 0.61 |
| ▸ | FLT4 | P35916 | 9/20 | 0.61 |
| ▸ | KDR | P35968 | 9/20 | 0.61 |
| ▸ | IMPDH2 | P12268 | 10/20 | 0.50 |
| ▸ | VCP | P55072 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5469678 | 0.86 | FLT1 (0.68) | FLT1FLT4KDRIMPDH2VCP | |
| SCHEMBL5464876 | 0.79 | FLT1 (0.77) | FLT1FLT4KDRIMPDH2VCP | |
| SCHEMBL5469587 | 0.78 | KDR (0.76) | FLT1FLT4KDRIMPDH2VCP | |
| SCHEMBL5319878 | 0.78 | FLT1 (0.76) | FLT1FLT4KDRIMPDH2VCP | |
| SCHEMBL5480404 | 0.77 | KDR (0.97) | FLT1FLT4KDRIMPDH2VCP | |
| SCHEMBL7719438 | 0.74 | IMPDH2 (0.76) | IMPDH2VCP | |
| SCHEMBL5480372 | 0.73 | FLT1 (0.69) | FLT1FLT4KDRIMPDH2VCP | |
| SCHEMBL5476166 | 0.72 | FLT1 (0.66) | FLT1FLT4KDRIMPDH2VCP | |
| SCHEMBL5477700 | 0.71 | KDR (0.76) | FLT1FLT4KDRIMPDH2VCP | |
| SCHEMBL5316678 | 0.70 | FLT1 (0.60) | FLT1FLT4KDRIMPDH2VCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189712-B2 | 1,3-Oxazole compounds for the treatment of cancer | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-13 | — | — | US | disclosed |