Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | AURKA | O14965 | 4/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 9/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 12/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 12/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 11/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 10/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | USP2 | O75604 | 7/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.49 |
| ▸ | TSHR | P16473 | 6/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25375789 | 0.93 | AURKA (0.55) | MAPTAURKARPS6KB1LMNACYP1A2 | |
| SCHEMBL27902365 | 0.89 | AURKA (0.55) | MAPTAURKARPS6KB1LMNACYP1A2 | |
| SCHEMBL1460958 | 0.87 | MAPT (0.72) | MAPTAURKARPS6KB1LMNATP53 | |
| SCHEMBL24399596 | 0.84 | AURKA (0.56) | MAPTAURKARPS6KB1LMNACYP1A2 | |
| SCHEMBL30401990 | 0.81 | AURKA (0.55) | MAPTAURKARPS6KB1LMNACYP1A2 | |
| SCHEMBL24399559 | 0.81 | AURKA (0.55) | MAPTAURKARPS6KB1LMNACYP1A2 | |
| SCHEMBL1462325 | 0.80 | MAPT (0.53) | MAPTAURKARPS6KB1LMNATP53 | |
| SCHEMBL24399745 | 0.79 | AURKA (0.71) | MAPTAURKARPS6KB1LMNACYP1A2 | |
| SCHEMBL12786652 | 0.79 | AURKA (0.61) | MAPTAURKARPS6KB1LMNATP53 | |
| SCHEMBL9930607 | 0.78 | MAPT (0.56) | MAPTAURKARPS6KB1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130018033-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2013-01-17 | — | — | US | disclosed |
| EP-2493865-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011025938-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2011-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018033-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | MAPT 1082/4885AURKA 1013/4885RPS6KB1 315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.