Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDX3X | O00571 | 3/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14008953 | 0.91 | PDE7A (0.46) | PDE7AKMT2AWNT3AHIF1AEPAS1 | |
| SCHEMBL14009017 | 0.85 | MAPK14 (0.44) | AURKAAURKBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL14008947 | 0.84 | PDE7A (0.46) | PDE7AKMT2ASMN1; SMN2NPC1TP53 | |
| SCHEMBL14009047 | 0.83 | CCR5 (0.44) | S1PR1FLT3ROCK2 | |
| SCHEMBL14009351 | 0.83 | RAB9A (0.42) | KMT2ATNIKSMN1; SMN2NPC1RAB9A | |
| SCHEMBL14009066 | 0.81 | RAB9A (0.41) | KMT2ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL14009089 | 0.80 | S1PR1 (0.42) | KMT2ANPC1RAB9AS1PR1ROCK2 | |
| SCHEMBL14009186 | 0.80 | MEN1 (0.48) | KMT2AHIF1AEPAS1SMN1; SMN2LMNA | |
| SCHEMBL14009024 | 0.79 | BLM (0.43) | PDE7AKMT2AWNT3AHIF1AEPAS1 | |
| SCHEMBL14009068 | 0.79 | RAB9A (0.44) | KMT2ANPC1RAB9AS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007022258-A1 | NOVEL HIGH AFFINITY THIOPHENE-BASED AND FURAN-BASED KINASE LIGANDS | SCHERING CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |