Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12046575 | 0.88 | HSP90AA1 (0.58) | MEN1KMT2AMAPTPOLBHSP90AA1 | |
| SCHEMBL12768521 | 0.71 | MAPT (0.75) | MEN1KMT2AMAPTPOLBHSP90AA1 | |
| SCHEMBL1147840 | 0.70 | HSP90AA1 (0.46) | MEN1KMT2AMAPTHSP90AA1LMNA | |
| SCHEMBL4874667 | 0.70 | MEN1 (0.62) | MEN1KMT2AMAPTPOLBHSP90AA1 | |
| SCHEMBL14396294 | 0.69 | MEN1 (0.54) | MEN1KMT2AMAPTPOLBHSP90AA1 | |
| SCHEMBL408306 | 0.68 | MEN1 (0.48) | MEN1KMT2AMAPTPOLBHSP90AA1 | |
| SCHEMBL4884535 | 0.68 | MEN1 (0.52) | MEN1KMT2AMAPTPOLBHSP90AA1 | |
| SCHEMBL1167358 | 0.67 | MEN1 (0.47) | MEN1KMT2AMAPTPOLBHSP90AA1 | |
| SCHEMBL38661842 | 0.66 | GPR84 (0.44) | MEN1KMT2AMAPTATMKDM4E | |
| SCHEMBL4931003 | 0.65 | ESR1 (0.44) | MEN1KMT2AMAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007021966-A1 | PYRAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2007-02-22 | — | — | WO | disclosed |