Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 11/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14610868 | 0.74 | NR1H3 (0.40) | NR1H3PTGS1PTPN1 | |
| SCHEMBL12704706 | 0.72 | PTPN1 (0.59) | NR1H3PTGS1PTPN1 | |
| SCHEMBL12704637 | 0.72 | SOD1 (0.47) | NR1H3PTGS1PTPN1NR1H2 | |
| SCHEMBL14610161 | 0.68 | NR1H3 (0.38) | NR1H3PTGS1PTPN1 | |
| SCHEMBL14610507 | 0.67 | CYP19A1 (0.39) | — | |
| SCHEMBL280157 | 0.61 | NR1H3 (0.46) | NR1H3PTGS1PTPN1NR1H2 | |
| SCHEMBL10224049 | 0.61 | PTGS1 (0.48) | NR1H3PTGS1PTPN1NR1H2 | |
| SCHEMBL12450190 | 0.60 | NR1H3 (0.67) | NR1H3PTGS1PTPN1 | |
| SCHEMBL263282 | 0.60 | NR1H3 (0.67) | NR1H3PTGS1PTPN1 | |
| SCHEMBL267202 | 0.60 | NR1H3 (0.67) | NR1H3PTGS1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015757-A2 | INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-A MODULATORS; SYNTHESES OF SUCH MODULATORS AND METHODS OF USING SUCH MODULATORS | NEREUS PHARMACEUTICALS, INC. (US) | 2007-02-08 | — | — | WO | disclosed |