Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045888 | 0.88 | KDR (0.65) | KDRMAPK14MAP2K1 | |
| SCHEMBL5739200 | 0.83 | KDR (0.46) | KDR | |
| SCHEMBL14451969 | 0.81 | CYP3A4 (0.45) | KDR | |
| SCHEMBL1226861 | 0.79 | KDR (1.00) | KDRMAPK14 | |
| SCHEMBL4045485 | 0.79 | KDR (1.00) | KDRMAPK14MAP2K1 | |
| SCHEMBL4100742 | 0.74 | MAPK14 (0.68) | KDRMAPK14 | |
| SCHEMBL1462064 | 0.72 | MAP2K1 (0.83) | KDRMAPK14MAP2K1 | |
| SCHEMBL1228138 | 0.71 | KDR (0.55) | KDRMAPK14MAP2K1 | |
| SCHEMBL4048067 | 0.71 | KDR (0.69) | KDRMAPK14MAP2K1 | |
| SCHEMBL1227728 | 0.70 | KDR (0.53) | KDRMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4649046-B2 | — | — | 2011-03-09 | — | — | JP | claimed |
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |
| US-6982265-B1 | Pyrrolotriazine inhibitors of kinases | BRISTOL MYERS SQUIBB COMPANY (US) | 2006-01-03 | — | — | US | claimed |
| JP-2003500359-A | — | — | 2003-01-07 | — | — | JP | claimed |
| EP-1183033-A4 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2002-07-17 | — | — | EP | claimed |
| EP-1183033-A1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-03-06 | — | — | EP | claimed |
| WO-2000071129-A1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-11-30 | — | — | WO | claimed |
| US-7244733-B2 | Pyrrolotriazine inhibitors of kinases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-17 | — | — | US | disclosed |