Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | KIF5B | P33176 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 12/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14451969 | 0.90 | CYP3A4 (0.45) | KDRRETKIF5BMETCYP3A4 | |
| SCHEMBL1461091 | 0.83 | KDR (0.65) | KDR | |
| SCHEMBL5739893 | 0.80 | KDR (0.71) | KDRRETKIF5B | |
| SCHEMBL5739048 | 0.73 | MAP2K1 (0.66) | KDR | |
| SCHEMBL5738800 | 0.72 | KDR (0.48) | KDRRETKIF5B | |
| SCHEMBL4045888 | 0.70 | KDR (0.65) | KDR | |
| SCHEMBL5739989 | 0.70 | KDR (0.53) | KDRRETKIF5B | |
| SCHEMBL5739937 | 0.70 | KDR (0.56) | KDR | |
| SCHEMBL14032273 | 0.69 | KDR (0.41) | KDRRETMETCYP3A4KCNH2 | |
| SCHEMBL5740473 | 0.69 | MAP2K1 (0.52) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |