Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 9/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | KIF5B | P33176 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 10/20 | 0.41 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | HCK | P08631 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739200 | 0.90 | KDR (0.46) | CYP3A4KDRRETKIF5BMET | |
| SCHEMBL1461091 | 0.81 | KDR (0.65) | KDR | |
| SCHEMBL14032273 | 0.71 | KDR (0.41) | CYP3A4KDRRETMETEPHB6 | |
| SCHEMBL14451958 | 0.71 | MAP2K1 (0.67) | KDREGFR | |
| SCHEMBL1227728 | 0.70 | KDR (0.53) | CYP3A4KDRRETMETEPHB6 | |
| SCHEMBL5739893 | 0.69 | KDR (0.71) | KDRRETKIF5BEGFRFGFR1 | |
| SCHEMBL4045888 | 0.68 | KDR (0.65) | KDREGFR | |
| SCHEMBL1683387 | 0.68 | SCN9A (0.43) | CYP3A4KDRMET | |
| SCHEMBL14451955 | 0.67 | KDR (0.53) | KDRMAP4K4EGFR | |
| SCHEMBL14451966 | 0.67 | MAP2K1 (0.52) | KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7244733-B2 | Pyrrolotriazine inhibitors of kinases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-17 | — | — | US | disclosed |