Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | ULK1 | O75385 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2369987 | 0.78 | MAPK1 (0.75) | MAPK1KDM4EGAAHDAC3HDAC1 | |
| SCHEMBL24220836 | 0.76 | MAPK1 (0.66) | MAPK1KDM4EGAAHDAC3HDAC1 | |
| SCHEMBL22570292 | 0.75 | MAPK1 (0.46) | MAPK1KDM4EGAAHDAC3HDAC1 | |
| SCHEMBL21258182 | 0.74 | GRM5 (0.45) | KDM4EALDH1A1GRM5ULK1 | |
| SCHEMBL2370002 | 0.74 | MAPK1 (0.48) | MAPK1KDM4EGAAHDAC3HDAC1 | |
| SCHEMBL14865392 | 0.74 | MAPK1 (0.48) | MAPK1KDM4EGAAHDAC3HDAC1 | |
| SCHEMBL248829 | 0.74 | MAPK1 (0.48) | MAPK1KDM4EGAAHDAC3HDAC1 | |
| SCHEMBL2949550 | 0.74 | MAPK1 (0.48) | MAPK1KDM4EGAAHDAC3HDAC1 | |
| SCHEMBL12524651 | 0.73 | MAPK1 (0.49) | MAPK1KDM4EGAAHDAC3HDAC1 | |
| SCHEMBL18084601 | 0.73 | MAPK1 (0.49) | MAPK1KDM4EGAAHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007022380-A2 | BIS-ARYL AMIDE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2007-02-22 | — | — | WO | disclosed |