Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ULK1 | O75385 | 1/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10187963 | 0.91 | KDM4E (0.53) | MAPK1KDM4EGAAHDAC3HDAC1 | |
| SCHEMBL22241886 | 0.79 | PCSK9 (0.51) | MAPK1KDM4EGAAALDH1A1 | |
| SCHEMBL2369987 | 0.77 | MAPK1 (0.75) | MAPK1KDM4EGAAHDAC3HDAC1 | |
| SCHEMBL2949550 | 0.77 | MAPK1 (0.48) | MAPK1KDM4EGAAHDAC3HDAC1 | |
| SCHEMBL248829 | 0.77 | MAPK1 (0.48) | MAPK1KDM4EGAAHDAC3HDAC1 | |
| SCHEMBL2370002 | 0.77 | MAPK1 (0.48) | MAPK1KDM4EGAAHDAC3HDAC1 | |
| SCHEMBL28447539 | 0.77 | KAT2B (0.45) | MAPK1HDAC1 | |
| SCHEMBL30807483 | 0.77 | ENPP2 (0.48) | — | |
| SCHEMBL31456618 | 0.76 | MAPK8 (0.34) | MAPK1MAPK8GRM5 | |
| Hydrochloric Acid SCHEMBL1669811 | 0.76 | MAPK1 (0.47) | MAPK1KDM4EGAAHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014078323-A1 | N-PYRROLIDINYL, N'-PYRAZOLYL- UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2014-05-22 | — | — | WO | disclosed |
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |