Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | PYGL | P06737 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13668215 | 0.92 | ITGAL (0.51) | ITGALMEN1KMT2AITGB1ITGA4 | |
| SCHEMBL3875155 | 0.84 | ADRB1 (0.47) | ITGALDRD3HTR2BSLC6A3CYP2D6 | |
| SCHEMBL13923450 | 0.82 | EGFR (0.44) | ITGALPOLBDRD3HTR2BSLC6A3 | |
| SCHEMBL13666886 | 0.81 | ITGAL (0.65) | ITGALITGB1ITGA4S1PR1DRD3 | |
| SCHEMBL7231159 | 0.81 | ITGAL (0.38) | ITGALMEN1KMT2AITGB1ITGA4 | |
| SCHEMBL14614027 | 0.80 | S1PR1 (0.43) | MEN1KMT2AITGB1ITGA4POLB | |
| SCHEMBL18867719 | 0.80 | ITGAL (0.59) | ITGALITGB1ITGA4S1PR1DRD3 | |
| SCHEMBL3868781 | 0.80 | ITGAL (0.49) | ITGALMEN1KMT2AITGB1ITGA4 | |
| SCHEMBL13666039 | 0.79 | ITGAL (0.47) | ITGALMEN1KMT2AITGB1ITGA4 | |
| SCHEMBL3868772 | 0.79 | ITGAL (0.76) | ITGALITGB1ITGA4HPGDOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1754705-A2 | Antagonists for treatment of CD11/CD18 adhesion receptor mediated disorders | Genentech, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1063982-B1 | ANTAGONISTS FOR TREATMENT OF CD11/CD18 ADHESION RECEPTOR MEDIATED DISORDERS | GENENTECH INC (US) | 2007-02-14 | — | — | EP | disclosed |