Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 1/20 | 0.57 |
| ▸ | TLR2 | O60603 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 2/20 | 0.50 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10021695 | 0.85 | TLR4 (0.64) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL12652658 | 0.84 | TLR4 (0.60) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL10963383 | 0.84 | TLR4 (0.60) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL14351190 | 0.84 | TLR4 (0.60) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8784209 | 0.84 | KDM4E (0.76) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8784206 | 0.84 | KDM4E (0.76) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL17680005 | 0.83 | TLR4 (0.61) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6320363 | 0.82 | MAOB (0.62) | SMN1; SMN2ALOX5PTGS1PTGS2CYP2D6 | |
| SCHEMBL6318820 | 0.82 | MAOB (0.62) | SMN1; SMN2ALOX5PTGS1PTGS2CYP2D6 | |
| SCHEMBL19244390 | 0.82 | APP (0.64) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1754705-A2 | Antagonists for treatment of CD11/CD18 adhesion receptor mediated disorders | Genentech, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |