Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.76 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | TLR4 | O00206 | 2/20 | 0.63 |
| ▸ | TLR2 | O60603 | 2/20 | 0.63 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 3/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8784206 | 1.00 | KDM4E (0.76) | KDM4EALDH1A1SMN1; SMN2PKMTLR4 | |
| SCHEMBL9717025 | 0.94 | KDM4E (0.72) | KDM4EALDH1A1SMN1; SMN2PKMTLR4 | |
| SCHEMBL7969956 | 0.94 | KDM4E (0.72) | KDM4EALDH1A1SMN1; SMN2PKMTLR4 | |
| SCHEMBL9717028 | 0.94 | KDM4E (0.72) | KDM4EALDH1A1SMN1; SMN2PKMTLR4 | |
| SCHEMBL7969953 | 0.94 | KDM4E (0.72) | KDM4EALDH1A1SMN1; SMN2PKMTLR4 | |
| SCHEMBL9015708 | 0.94 | KDM4E (0.72) | KDM4EALDH1A1SMN1; SMN2PKMTLR4 | |
| SCHEMBL7970157 | 0.94 | KDM4E (0.72) | KDM4EALDH1A1SMN1; SMN2PKMTLR4 | |
| SCHEMBL7970153 | 0.94 | KDM4E (0.72) | KDM4EALDH1A1SMN1; SMN2PKMTLR4 | |
| SCHEMBL28397202 | 0.93 | KDM4E (0.78) | KDM4EALDH1A1SMN1; SMN2PKMTLR4 | |
| SCHEMBL28397201 | 0.93 | KDM4E (0.78) | KDM4EALDH1A1SMN1; SMN2PKMTLR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0595995-B1 | ARYLAMIDOALKYL- AND ARYLAMINOALKYL-N-HYDROXYUREA COMPOUNDS AND -N-HYDROXYFORMAMIDE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1997-01-15 | — | — | EP | disclosed |
| US-5514702-A | Arylamidoalkyl-N-hydroxyurea compounds having lipoxygenase inhibitory activity | ABBOTT LABORATORIES (US) | 1996-05-07 | — | — | US | disclosed |
| EP-0595995-A4 | ARYLAMIDOALKYL-N-HYDROXYUREA COMPOUNDS HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1994-08-24 | — | — | EP | disclosed |
| EP-0595995-A1 | ARYLAMIDOALKYL-N-HYDROXYUREA COMPOUNDS HAVING LIPOXYGENASE INHIBITORY ACTIVITY. | ABBOTT LAB (US) | 1994-05-11 | — | — | EP | disclosed |
| WO-1993002037-A1 | ARYLAMIDOALKYL-N-HYDROXYUREA COMPOUNDS HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1993-02-04 | — | — | WO | disclosed |