Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.76 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | TLR4 | O00206 | 2/20 | 0.63 |
| ▸ | TLR2 | O60603 | 2/20 | 0.63 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 3/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8784209 | 1.00 | KDM4E (0.76) | KDM4EALDH1A1SMN1; SMN2PKMTLR4 | |
| SCHEMBL9717025 | 0.94 | KDM4E (0.72) | KDM4EALDH1A1SMN1; SMN2PKMTLR4 | |
| SCHEMBL7969956 | 0.94 | KDM4E (0.72) | KDM4EALDH1A1SMN1; SMN2PKMTLR4 | |
| SCHEMBL9717028 | 0.94 | KDM4E (0.72) | KDM4EALDH1A1SMN1; SMN2PKMTLR4 | |
| SCHEMBL7969953 | 0.94 | KDM4E (0.72) | KDM4EALDH1A1SMN1; SMN2PKMTLR4 | |
| SCHEMBL9015708 | 0.94 | KDM4E (0.72) | KDM4EALDH1A1SMN1; SMN2PKMTLR4 | |
| SCHEMBL7970157 | 0.94 | KDM4E (0.72) | KDM4EALDH1A1SMN1; SMN2PKMTLR4 | |
| SCHEMBL7970153 | 0.94 | KDM4E (0.72) | KDM4EALDH1A1SMN1; SMN2PKMTLR4 | |
| SCHEMBL28397202 | 0.93 | KDM4E (0.78) | KDM4EALDH1A1SMN1; SMN2PKMTLR4 | |
| SCHEMBL28397201 | 0.93 | KDM4E (0.78) | KDM4EALDH1A1SMN1; SMN2PKMTLR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9840515-B2 | Protein kinase D inhibitors | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-12-12 | — | — | US | disclosed |
| US-20160102047-A1 | SUBSTITUTED N-PENTANAMIDE COMPOUNDS, PREPARATION METHOD AND THE USE THEREOF | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2016-04-14 | — | — | US | disclosed |
| US-9249084-B2 | Substituted n-pentanamide compounds, preparation method and the use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2016-02-02 | — | — | US | disclosed |
| US-20140045821-A1 | PROTEIN KINASE D INHIBITORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2014-02-13 | — | — | US | disclosed |
| US-20140046074-A1 | Substituted n-pentanamide compounds, preparation method and the use thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-02-13 | — | — | US | disclosed |
| WO-2013090161-A1 | STEREOSELECTIVE SYNTHESIS OF TAPENTADOL AND ITS SALTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-06-20 | — | — | WO | disclosed |
| US-20130150622-A1 | STEREOSELECTIVE SYNTHESIS OF TAPENTADOL AND ITS SALTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-06-13 | — | — | US | disclosed |
| WO-2012078859-A2 | PROTEIN KINASE D INHIBITORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-06-14 | — | — | WO | disclosed |
| EP-0595995-B1 | ARYLAMIDOALKYL- AND ARYLAMINOALKYL-N-HYDROXYUREA COMPOUNDS AND -N-HYDROXYFORMAMIDE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1997-01-15 | — | — | EP | disclosed |
| US-5514702-A | Arylamidoalkyl-N-hydroxyurea compounds having lipoxygenase inhibitory activity | ABBOTT LABORATORIES (US) | 1996-05-07 | — | — | US | disclosed |
| EP-0595995-A4 | ARYLAMIDOALKYL-N-HYDROXYUREA COMPOUNDS HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1994-08-24 | — | — | EP | disclosed |
| EP-0595995-A1 | ARYLAMIDOALKYL-N-HYDROXYUREA COMPOUNDS HAVING LIPOXYGENASE INHIBITORY ACTIVITY. | ABBOTT LAB (US) | 1994-05-11 | — | — | EP | disclosed |
| WO-1993002037-A1 | ARYLAMIDOALKYL-N-HYDROXYUREA COMPOUNDS HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1993-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102047-A1 | SUBSTITUTED N-PENTANAMIDE COMPOUNDS, PREPARATION METHOD AND THE USE THEREOF | PNMT, TPMT, HTR3A | KDM4E 225/4885ALDH1A1 1040/4885SMN1; SMN2 476/4885 |
| US-20140045821-A1 | PROTEIN KINASE D INHIBITORS | PRKCD, PRKD1, PRKD2 | KDM4E 1875/4885ALDH1A1 4548/4885SMN1; SMN2 4309/4885 |
| US-20130150622-A1 | STEREOSELECTIVE SYNTHESIS OF TAPENTADOL AND ITS SALTS | SLC6A2, SLC6A4, SLC6A6 | KDM4E 1955/4885ALDH1A1 891/4885SMN1; SMN2 1578/4885 |
| US-20140046074-A1 | Substituted n-pentanamide compounds, preparation method and the use thereof | PNMT, TPMT, HTR3A | KDM4E 223/4885ALDH1A1 1012/4885SMN1; SMN2 476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.