Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | P2RY14 | Q15391 | 6/20 | 0.43 |
| ▸ | CETP | P11597 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DUSP1 | P28562 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2624628 | 0.73 | HPGD (0.72) | MAPTP2RY14HPGDALDH1A1GAA | |
| SCHEMBL2624626 | 0.73 | MAPT (0.71) | MAPTP2RY14HPGDMEN1NPC1 | |
| SCHEMBL4308051 | 0.70 | TP53 (0.55) | MAPTHPGDMEN1ALDH1A1KMT2A | |
| SCHEMBL4513646 | 0.68 | MAPT (0.56) | MAPTP2RY14MEN1KMT2ADUSP1 | |
| SCHEMBL12167405 | 0.67 | SIRT1 (0.46) | MAPTHPGDMEN1ALDH1A1KMT2A | |
| SCHEMBL11696963 | 0.64 | MAPT (0.47) | MAPTCETPMEN1NPC1RAB9A | |
| SCHEMBL26390953 | 0.63 | SMN1; SMN2 (0.59) | MAPTCETPHPGDMEN1NPC1 | |
| SCHEMBL28887841 | 0.60 | P2RY14 (1.00) | MAPTP2RY14HPGDMEN1NPC1 | |
| SCHEMBL30153413 | 0.60 | P2RY14 (1.00) | MAPTP2RY14HPGDMEN1NPC1 | |
| SCHEMBL2950808 | 0.60 | ESR2 (0.62) | MAPTCETPHPGDNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007019417-A1 | OXAZOLOPYRIDINE DERIVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |