SCHEMBL14614733 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	SIRT1	Q96EB6	13/20	0.55

▸	CHRM2	P08172	1/20	0.55

▸	ADRA2A	P08913	1/20	0.55

▸	CHRM1	P11229	1/20	0.55

▸	SLC6A2	P23975	1/20	0.55

▸	SIRT2	Q8IXJ6	1/20	0.55

▸	SIRT3	Q9NTG7	1/20	0.55

▸	HTR1A	P08908	2/20	0.36

▸	DRD4	P21917	2/20	0.36

▸	JAK3	P52333	3/20	0.35

▸	JAK2	O60674	2/20	0.35

▸	JAK1	P23458	2/20	0.35

▸	TYK2	P29597	2/20	0.35

▸	EGFR	P00533	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2624441	0.83	SIRT1 (0.67)	SIRT1CHRM2ADRA2ACHRM1SLC6A2
SCHEMBL14607769	0.81	SIRT1 (0.70)	SIRT1CHRM2ADRA2ACHRM1SLC6A2
SCHEMBL2740333	0.80	SIRT1 (0.82)	SIRT1CHRM2ADRA2ACHRM1SLC6A2
SCHEMBL2624440	0.76	SIRT1 (0.48)	SIRT1CHRM2ADRA2ACHRM1SLC6A2
SCHEMBL4789284	0.75	SIRT1 (0.49)	SIRT1CHRM2ADRA2ACHRM1SLC6A2
SCHEMBL220301	0.75	SIRT1 (0.48)	SIRT1CHRM2ADRA2ACHRM1SLC6A2
SCHEMBL221933	0.75	SIRT1 (0.48)	SIRT1CHRM2ADRA2ACHRM1SLC6A2
SCHEMBL219156	0.75	SIRT1 (0.48)	SIRT1CHRM2ADRA2ACHRM1SLC6A2
SCHEMBL2740335	0.73	SIRT1 (0.86)	SIRT1CHRM2ADRA2ACHRM1SLC6A2
SCHEMBL4818916	0.73	SIRT1 (0.44)	SIRT1CHRM2ADRA2ACHRM1SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2007019417-A1	OXAZOLOPYRIDINE DERIVATIVES AS SIRTUIN MODULATORS	SIRTRIS PHARMACEUTICALS, INC. (US)	2007-02-15	—	—	WO	disclosed