Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 13/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL221933 | 0.88 | SIRT1 (0.48) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL2624440 | 0.88 | SIRT1 (0.48) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL219156 | 0.88 | SIRT1 (0.48) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL221866 | 0.83 | SIRT1 (0.50) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL221222 | 0.78 | SIRT1 (0.46) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL2624441 | 0.77 | SIRT1 (0.67) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL4818916 | 0.75 | SIRT1 (0.44) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL14614733 | 0.75 | SIRT1 (0.55) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL4818911 | 0.74 | SIRT1 (0.42) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL14886520 | 0.73 | SIRT1 (0.66) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910380-A1 | OXAZOLOPYRIDINE DERIVATIVES AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007019417-A1 | OXAZOLOPYRIDINE DERIVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |