Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 8/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.37 |
| ▸ | TSHR | P16473 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2740280 | 0.81 | SIRT1 (0.47) | MEN1KMT2ASMN1; SMN2LMNAHPGD | |
| SCHEMBL2740257 | 0.67 | L3MBTL1 (0.61) | TSHRMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL2624496 | 0.67 | SIRT1 (0.60) | SMN1; SMN2LMNAKDM4EALDH1A1NPSR1 | |
| SCHEMBL2740276 | 0.67 | SIRT1 (0.45) | CYP1A2MEN1KMT2ACYP2C19SMN1; SMN2 | |
| SCHEMBL2740274 | 0.66 | TRPV1 (0.46) | CYP1A2MEN1KMT2ACYP2C19SMN1; SMN2 | |
| SCHEMBL2740277 | 0.66 | SIRT1 (0.49) | CYP1A2MEN1KMT2ACYP2C19CYP2C9 | |
| SCHEMBL2740278 | 0.66 | KIT (0.44) | LMNAMAPT | |
| SCHEMBL2740258 | 0.66 | MAPT (0.51) | MEN1KMT2ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL2740275 | 0.65 | PDCD1 (0.51) | TSHRKMT2ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL2740256 | 0.64 | MAPT (0.59) | TSHRMEN1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007019417-A1 | OXAZOLOPYRIDINE DERIVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |