Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | RAB9A | P51151 | 3/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | NRP1 | O14786 | 2/20 | 0.62 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.55 |
| ▸ | HSF1 | Q00613 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | PIR | O00625 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13679583 | 0.94 | MAPT (0.80) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL14615273 | 0.89 | MAPT (0.89) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL13679557 | 0.86 | MEN1 (0.60) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL14615308 | 0.84 | MAPT (0.65) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL13679622 | 0.83 | NRP1 (0.83) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL14615284 | 0.83 | MAPT (1.00) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL14642489 | 0.81 | MEN1 (0.69) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL14615283 | 0.81 | MEN1 (0.68) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL13679564 | 0.81 | MAPT (0.70) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL13679542 | 0.80 | MEN1 (0.62) | MAPTMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772275-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8772275-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |