Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | COMT | P21964 | 1/20 | 0.47 |
| ▸ | LDLR | P01130 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14615282 | 0.90 | MAPT (0.68) | MAPTDGAT1LMNAMEN1KMT2A | |
| SCHEMBL13679715 | 0.89 | MAPT (0.69) | MAPTDGAT1LMNAMEN1RAB9A | |
| SCHEMBL13679575 | 0.82 | MAPT (0.73) | MAPTLMNAMEN1KMT2ACOMT | |
| SCHEMBL13679599 | 0.82 | MGAM (0.57) | MAPTDGAT1LMNAMEN1RAB9A | |
| SCHEMBL13679552 | 0.81 | MAPT (0.69) | MAPTTHRBMEN1KMT2ATP53 | |
| SCHEMBL14642415 | 0.80 | MAPT (0.65) | MAPTDGAT1LMNAMEN1KMT2A | |
| SCHEMBL13679579 | 0.80 | PDE2A (0.53) | MAPTDGAT1LMNAMEN1RAB9A | |
| SCHEMBL15424127 | 0.79 | MAPT (0.68) | MAPTDGAT1MEN1KMT2ACOMT | |
| SCHEMBL14615308 | 0.79 | MAPT (0.65) | MAPTTHRBLMNAMEN1RAB9A | |
| SCHEMBL2157955 | 0.78 | MAPT (0.65) | MAPTLMNAMEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |