Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HPD | P32754 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14615685 | 0.93 | HPD (0.51) | MAPK14LMNAL3MBTL1HPDMAPT | |
| SCHEMBL4197942 | 0.81 | LMNA (0.57) | LMNAL3MBTL1MAPTDRD2SLC6A4 | |
| SCHEMBL25446875 | 0.81 | MAPK14 (0.47) | MAPK14HPDMAPTBRPF1BRD4 | |
| SCHEMBL13322666 | 0.79 | MAPK14 (0.59) | MAPK14HPDMAPTTHRBBRPF1 | |
| SCHEMBL14615683 | 0.79 | CHEK1 (0.42) | LMNAL3MBTL1HPDMAPTTHRB | |
| SCHEMBL13140197 | 0.76 | HPD (0.54) | LMNAL3MBTL1HPDMAPTTHRB | |
| SCHEMBL12139324 | 0.76 | SLC6A2 (0.50) | LMNAHPDBRPF1BRD4ALDH1A1 | |
| SCHEMBL30049030 | 0.76 | SLC22A12 (0.57) | MAPK14HPDBRPF1BRD4HPGD | |
| SCHEMBL24815336 | 0.76 | SLC22A12 (0.57) | MAPK14HPDBRPF1BRD4HPGD | |
| SCHEMBL27446315 | 0.76 | MAPK14 (0.43) | MAPK14HPDMAPTBRPF1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007022257-A2 | MONOCYCLIC AND BICYCLIC COMPOUNDS AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-02-22 | — | — | WO | disclosed |