⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL170744 | 0.93 | — | — | |
| SCHEMBL170981 | 0.93 | — | — | |
| SCHEMBL173550 | 0.93 | — | — | |
| SCHEMBL5786025 | 0.80 | — | — | |
| SCHEMBL1219812 | 0.78 | — | — | |
| SCHEMBL6635003 | 0.78 | CYP2D6 (0.31) | — | |
| SCHEMBL8860690 | 0.77 | — | — | |
| SCHEMBL6050209 | 0.74 | ALDH1A1 (0.32) | — | |
| SCHEMBL693202 | 0.73 | — | — | |
| SCHEMBL11103722 | 0.73 | NOS1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024045066-A1 | ALKYLIDENE CARBAMATE AS KRAS INHIBITORS | NIKANG THERAPEUTICS, INC. (US) | 2024-03-07 | — | — | WO | claimed |
| WO-2024046406-A1 | ALKYLIDENE CARBAMATE AS KRAS INHIBITORS | NIKANG THERAPEUTICS, INC. (US) | 2024-03-07 | — | — | WO | claimed |
| CN-114126713-B | Substituted benzimidazolone compounds | 百时美施贵宝公司 | 2023-12-08 | — | — | CN | claimed |
| US-20220289739-A1 | SUBSTITUTED BENZIMIDAZOLONE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2022-09-15 | — | — | US | claimed |
| CN-114126713-A | Substituted benzimidazolone compounds | 百时美施贵宝公司 | 2022-03-01 | — | — | CN | claimed |
| WO-2020227484-A1 | SUBSTITUTED BENZIMIDAZOLONE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-11-12 | — | — | WO | claimed |
| US-4925849-A | DIURETICS, HYPOTENSIVE AGENTS, CARIOTONIC AGENTS AND ANTIEDEMIC AGENTS | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1990-05-15 | — | — | US | claimed |
| EP-0299209-A2 | Pyrazolopyridine compound and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-01-18 | — | — | EP | claimed |
| WO-2024149214-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING KRAS-12D VIA UBIQUITIN PROTEASOME PATHWAY | NIKANG THERAPEUTICS, INC. (US) | 2024-07-18 | — | — | WO | disclosed |
| WO-2024138486-A1 | TETRACYCLIC DERIVATIVES AS KRAS INHIBITORS | NIKANG THERAPEUTICS, INC. (US) | 2024-07-04 | — | — | WO | disclosed |
| WO-2024051721-A1 | TETRACYCLIC DERIVATIVES AS KRAS INHIBITORS | NIKANG THERAPEUTICS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |
| WO-2024050742-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING KRAS G12D VIA UBIQUITIN PROTEASOME PATHWAY | NIKANG THERAPEUTICS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |
| WO-2024046406-A1 | ALKYLIDENE CARBAMATE AS KRAS INHIBITORS | NIKANG THERAPEUTICS, INC. (US) | 2024-03-07 | — | — | WO | disclosed |
| WO-2024045066-A1 | ALKYLIDENE CARBAMATE AS KRAS INHIBITORS | NIKANG THERAPEUTICS, INC. (US) | 2024-03-07 | — | — | WO | disclosed |
| US-5102878-A | Treating psychological, bone, cardiovascular, blood disorders | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-07 | — | — | US | disclosed |
| US-5087629-A | Diuretics, hypotensive agents; cardiotonic agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-02-11 | — | — | US | disclosed |
| US-4994453-A | Treating asthma, diabetes, obesity, immunosuppression | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-19 | — | — | US | disclosed |
| US-4925849-A | DIURETICS, HYPOTENSIVE AGENTS, CARIOTONIC AGENTS AND ANTIEDEMIC AGENTS | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1990-05-15 | — | — | US | disclosed |
| EP-0360701-A1 | Antifungal compounds containing amides and phenyl groups | RHONE-POULENC AGROCHIMIE (FR) | 1990-03-28 | — | — | EP | disclosed |
| EP-0299209-A2 | Pyrazolopyridine compound and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-01-18 | — | — | EP | disclosed |